Adverse Effects of the Pesticide, Aldrin
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Until the early 1970s the pesticide, aldrin, was widely employed for a variety of purposes. Since then though, concern over its possible adverse effects has caused the chemical's use to be progressively restricted. These concerns include its potential for bioaccumulation in the environment, as well as its possible carcinogenicity. Past research has shown that aldrin causes an increased incidence of benign and malignant liver tumors in mice. These data have led to an examination of overly exposed humans namely, workers in insecticide factories. The studies concluded, however, that there was no evidence of aldrin's carcinogenicity. "Aldrin" is the common name approved by the International Standards Organization for a product containing not less than 95% of 1,2,3,4,10,10 hexachloro 1,4,4a,5,8,8a hexahydro exo 1,4 endo 5,8 dimethanonaphthalene (7:1). In Canada, aldrin refers to the pure compound which, in Britain, is also known as hexachlorohexahydrodimethano naphthalene (HHDN) (7:1). Technical aldrin is actually a complex mixture of compounds (7:1). The substance exists as a dark brown solid (4:5). Typically, it is used in various formulations which may include emulsifiable concentrates, wettable powders, granules, dusts, and solutions in hydrocarbon liquids (6:47). See below for a diagram of aldrin's chemical structure (4:6): A chlorinated cyclodiene pesticide, aldrin, was manufactured between 1950 and 1990 (4:
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e to man's daily intake (1:65,4:31).
These investigations eventually led to restriction of aldrin use to specific applications which neither give rise to residues in food nor have any adverse environmental effects (4:3). Thus aldrin may still be used in some countries for termite control (4:3). This is because concentrations in the air of aldrin treated houses were found to decrease rapidly after a period of 8 weeks (4:32). Since the mid 1970s though, the different restrictions have resulted in a measurable decline in dieldrin adipose tissue concentrations in the U.S.A., the U.K., and The Netherlands (4:32).
One specific population, however, which has certainly been highly exposed to aldrin includes the insecticide factory workers themselves. The most important route of exposure for occupationally exposed workers is via the skin (6:31). Following absorption, aldrin is rapidly distributed to the organs and tissues of the body, and a continuous exchange between the blood and other tissues is initiated (4:14). In the liver, aldrin is rapidly converted to dieldrin (4:14). Dieldrin is metabolized at a much lower rate; since excretion is slow, dieldrin tends to accumulate in body tissues primarily, in adipose tissue (4:14).
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Some common words found in the essay are:
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Approximate Word count = 4280
Approximate Pages = 17 (250 words per page)
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