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Genistein Soybean & Breast Cancer

This is an excerpt from the paper...

When it comes to breast cancer, many agents are thought to play a role in its formation. Genetics is believed to account for only 10-15% of breast cancer cases (Lamartiniere S1705). Because of such beliefs, many scientists and researchers believe that nutrition as well as other factors may be responsible for the development of breast cancer. One ingredient of soy foods, genistein, one of many isoflavones, is thought to have a weak estrogenic effect and studies on genistein have shown that the isoflavone is able to inhibit growth of estrogen-independent human breast cancer cells “Genistein inhibited cell proliferation in vitro by 50%” (Santell, Kieu, and Helferich 1665). Of course, these results were achieved in culture and not seen in mice under similar testing.

While researchers are still divided on the mechanisms by which soy foods work their effects and which components of them are most successful in preventing breast cancer, research studies support a connection between soy foods and breast cancer prevention. This analysis will discuss genistein, a soy isoflavone, and its potential to help prevent breast cancer development.

Genistein is though to exhibit a weak estrogenic effect. Genistein and soy foods are popular with nutritionists and others because it they are natural agents. Genistein, because of its weak estrogenic effect, is classified among the phyto-estrogens, a group of naturally occurring e

. . .
n Asian-Americans, including those who were born in America and those who emigrated here. Her study found that women born in America ate less soy foods than their émigré counterparts, and in those who at higher levels of soy foods there was a decreased risk of breast cancer: There was a higher risk for breast cancer in women who were born in the U.S., and with increasing weight and especially with increasing height. Tofu intake creased with years of residence in the U.S. and was twice as high among foreign-born women than those born in the U.S. Risk of breast cancer decreased with increasing intake of tofu; this was found in pre- and postmenopausal women. The association remained after adjustment for weight, height, reproductive factors and selected other dietary factors. The average tofu intake for foreign-born women was 62 times per year. (The Soybean 2) The much lower risk of breast, colon, and prostrate cancers in Asians who ingest 2050 times more soy per capita than Americans, originally led researchers to investigate whether a diet high in soy may act as a natural chemopreventive agent (Zhou and Lee 381). Since then genistein and other isoflavones have proven to act as inhibitors of cell proliferation of in vitro
. . .

Some common words found in the essay are:
Zhou Lee, BODY Genistein, Genistein Daidzein, Anna Wu, Kieu Helferich, Lamartiniere S1705, breast cancer, Nutrition Vol, Connection INTRODUCTION, Helferich Genistein, soy foods, S1705-S1707 Li, research studies, cancer prevention, zhou lee, risk breast, mammalian stress response, mammalian stress, breast cancer cells, risk breast cancer, cancer cells, stress response, nutrition vol, weak estrogenic effect, human breast cancer,
Approximate Word count = 1616
Approximate Pages = 6 (250 words per page)

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