Left Temporal Lobe Resectioning and Memory

Impaired verbal memory has consistently been associated with left dominant temporal lobe resection, and nonverbal memory impairment with right temporal lobe resection, but less reliably so (Pillon et al, 1999, 561-571). This dissociation may be due to material-specific differences in processing between verbal and nonverbal information, or the influence of the right and left limbic structures may vary with the stage of memory processing. Pillon et al examined these factors in a study comparing verbal and spatial learning in patients with right or left temporal lobe resection for intractable epilepsy using verbal and visuospatial memory tasks encompassing encoding, multiple trial learning, free and cued recall, and short and long delays. They found a similar pattern of learning in the two groups, a higher performance in spatial learning in patients with left temporal lobe resection and in verbal reasoning for patients with right temporal lobe resectioning, and material-specific effects giving a higher sensitivity to cues in the verbal domain and a better retention of information during delays in the s

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with delay. These findings suggest a mild impairment in the perception of complex patterns after right temporal lobe resection, and a more severe effect on retention of the perceived material. A study comparing the nose-referenced event-related potentials (ERPs) of 'old/new effect' for words presented in visual and auditory modalities showed the expected old/new effect in both modalities, with a comparable time course, and a more anterior scalp topography for visual items (Kayser et al, 2003, 11-25). This suggests a common cognitive process associated with separable neural generators in each modality. Despite temporal synchronization, the old/new effect overlapped ERP components having distinct scalp topographies or peak latencies for each modality. Methods Subjects The subjects for this experiment were patients with either right temporal lobe lesions (17 patients) or left temporal lobe lesions (16 patients). The control group contained normal, healthy subjects (38 subjects) with no brain lesions. The three groups were matched for age, gender, and level of education. Test Material The pair association format was used for the memory tasks. The test consisted of 8 verbal pairs and 8 visual pairs. The 8 words used
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