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Bone Marrow Transplantation
One application of im |
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One application of immunological methods to the treatment of human disease is bone marrow transplantation. During the 1960s, various technological advances led to the rapid development of this therapeutic modality. Perhaps the most important of advance occurred in the field of transplantation immunology. Since that time, bone marrow transplantation techniques have acquired considerable sophistication. Currently, transplantation is used for a variety of disorders including the leukemias, severe combined immunodeficiency states, osteoporosis, and various inherited diseases. In addition, it is also being investigated as a possible therapeutic tool against certain solid tumors. The procedure involved in bone marrow transplantation is relatively simple (2:519). Multiple bone marrow aspirations are simply taken from a donor and transfused into a recipient. For transplant engrafting to occur, the donor and recipient must be matched with respect to their major histocompatibility antigens. Thus, donors should be an identical twin (syngeneic); another closely related individual such as a sibling (allogenic); or the patient himself (autologous) (2:519).
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Category: Medical - B
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Marrow Transplantation, bone marrow, Medical Association, marrow transplantation, bone marrow transplantation, Klingemann Phillips, acute leukemia, Ikpeazu Bone, NY Springer Verlag, Journal Cancer, stem cells, Literature Cited, transplantation techniques, allogenic transplantation remission, transplantation remission, allogenic transplantation, transplantation employed, therapeutic modality, long term survival, marrow transplantation techniques, marrow transplantation employed,
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