DES Risks

From the 1940s to 1971, diethylstilbestrol (DES), a synthetic form of estrogen, was used as an antiabortive agent, but it wasn't until the 1990s that it was proven to have carcinogenic properties, putting the daughters of women who took it at risk for clear cell adenocarcinoma (Miller, 1999, 1362). By 1953, its antiabortive effects were disproved, yet it wasn't until 1971 that the U.S. Food and Drug Administration (FDA) issued a warning about its side effects. Back in 1989, the initial findings of a historical cohort study of over 6,000 women who had taken DES during pregnancy and were followed for up to 29 years had a total of 198 incidents of breast cancer, which was a moderate increase associated with taking DES (Colton et al, 1993, 2096-2100). The study also suggested that the risk became greater over time, with no increase being found in the first 20 years, but the relative risk between 20 and 25 years later was 1.6, and after 30 ye

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Category: Medical - D