MAJOR DEPRESSIVE DISORDER This research paper p

Major Depressive Disorder is a diagnostic classification involving a clinical course characterized by one or more Major Depressive Episodes with a lack of historical Manic, Mixed, or Hypomanic Episodes. This diagnosis also rules out mood disorders due to substance or drug abuse, medication, toxin exposure, or medical conditions; depressive symptoms must not be accounted for Schizoaffective Disorder or be superimposed on Schizophrenia, Schizophreniform Disorder, Delusional Disorder, or Psychotic Disorder Not Otherwise Specified (American Psychiatric Association [APA], 1994, p. 339).

Major Depressive Disorder can include either a single episode or it can be recurrent. For an episode to be specified as Single Episode, criteria for Major Depressive Episode must not have been met for two consecutive months following depression. Specifiers for the diagnosis include Mild, Moderate, Severe Without Psychotic Features or Severe With Psychotic Features, Chronic, With Catatonic Features, With Melancholic Features, With Atypical Features, or With Postpartum Onset; the disorder may be In Partial Remission or In Full Remission (APA, 1994, pp. 339-340).

This disorder may be preceded by Dysthymic Disorder (10% - 25%), and it is associated with a high mortality (15% die by suicide). Other disorders frequently associated with Major

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