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Cells Communicating with their Environment

This is an excerpt from the paper...

Cells need to communicate with their environment so they can respond appropriately (Overview, 2005). The external signal to the cell may come from one of four major pathways: hydrophobic molecules, ion channels, G-protein-coupled receptors, or enzymes. The signal often continues to propagate through the cell and may reach the nuclear DNA to induce the expression of proteins. Hydrophilic molecules can move in and out of cells by passing through the lipid bilayer. Nitric oxide (NO), arachidonic acid and steroids play important roles in cell signaling. With NO and arachidonic acid, cascades do not occur within the same cell, but newly generated nitric oxide and arachidonic acid diffuse to react with target molecules on neighboring cells.

NO may stimulate soluble guanylyl cyclase to produce cGMP which is used to regulate several enzymes and ion channels, and relaxes smooth muscle (Overview, 2005). Normally, cGMP is soon converted to GMP by phosphodiesterase. Arachidonic acid is generated from phospholipid hydrolysis catalyzed by phospholipase. Its target is usually on another cell also, and it may activate protein kinase, resulting in phosphorylation of target molecules. Its target molecules are often involved in neural activities including learning.

The main role of steroids is in regulating transcription, and many steroid receptors are transcription factors (Overview, 2005). The bound steroid receptor may recruit steroid receptor coactivator (SRC) and histone a

. . .
s. Small G proteins such as Ras, Rac and Rap activate MAPKKK, the kinase of MAPKK, to produce the MAPKK which is the kinase of MAPK, and produces MAPK. Three major MAPK pathways have been identified in mammals: MAPK/ERK, SAPK/JNK and p38 MAPK. Receptors are complex molecules which interact specifically with certain substances in the environment (Agullo, 2005). After binding of these substances, receptors undergo an alteration of their tridimensional structure which results in the production of enzymes which changes the concentration of certain molecules within the cell, known as second messengers, which mediate the final response of the cell to the environmental modification detected by the receptor. Sometimes the receptors synthesize the second messengers, but more often other complex molecules that interact with the receptors are needed to produce the second messengers. There are three general types of signal transducing receptors (King, 2004). The first is receptors that penetrate the plasma membrane and have intrinsic enzymatic activity, such as the tyrosine kinases (PDGF, insulin, EGF and FGF receptors), tyrosine phosphatases (CDA45 protein of T cells and macrophages), guanylyl cyclases (natriuretic peptide recepto
. . .

Some common words found in the essay are:
, EGF FGF, SMRT NcoR, Repeats VNTR, MAPK Receptors, MDA-MB-468 MDA-MB-231, Cancer-associated MUC1, Retrieved Feb, Intracellular PTPs, PTPs King, extracellular domain, feb 27 2005, 27 2005, ion channels, hormone receptors, arachidonic acid, overview 2005, retrieved feb, signal transduction, protein kinase, feb 27, retrieved feb 27, transmembrane domains extracellular, signal transduction retrieved, cytoplasmic transmembrane domains,
Approximate Word count = 1622
Approximate Pages = 6 (250 words per page)

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