Salmonellae Chracteristics
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Salmonellae are a Gram-negative, flagellated, facultative anaerobes of the family Enterobacteriaceae (Giannella; Morphology). They are, small, rod-shaped bacilli, with a polysaccharide capsule characterized by their O, H and V antigens. The organisms produce H2S from inorganic sulfur and produce acid and gas from glucose, with the exception of S. typhi which is a non-gas producer and only produces minimal H2S. Salmonella are relatively resistant to bile salts and this trait can be utilized for selective isolation media. They reduce nitrates (NO3 to NO2 or all the way to N2) and are oxidase negative. Salmonella do not ferment lactose. They are endergonic, using glucose for energy. The bacteria are readily isolated from stool specimens or rectal swabs on selective/differential agar media (e.g. XLD, XLT-4, SS or brilliant green agar supplemented with novobiocin. There were over 2501 recognized strains of Salmonellae identified as of 2004, but human infections are caused almost exclusively by serotypes Salmonella typhi and Salmonella paratyphi which cause enteric fever, Salmonella typhimurium which causes enteritis, Salmonella enteritidis which causes enteritis, and Salmonella choleraesuis which causes septicemia (Barrali; Morphology; World). Taxonomically, all strains of Salmonellae fall within one species, S. enterica, but they continue to be recognized by species names. The optimum growth temperature for most Salmonellae serotypes, including S. typhi, is 3
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depending on the serotype of the organism and the effectiveness of the host defense system, some organisms may infect the liver, spleen, gall bladder, bones, meninges, and other organs. Most serotypes are killed rapidly in extraintestinal sites, and the most common type, the Salmonella infection causing gastroenteritis, remains in the intestine.
Most Salmonellae induce an inflammatory response after invading the intestine and this may cause ulceration (Giannella). They may produce cytotoxins that inhibit protein synthesis, and may or may not contribute to the inflammatory process and ulceration. Invasion of the mucosa by the bacteria causes the epithelial cells to synthesize inflammatory cytokines which include IL-1, IL-6, IL-8, TNF-2, IFN-U, MCP-1 and GM-CSF, which invoke an acute inflammatory response capable of damaging the intestine, and producing symptoms of chills, fever, abdominal pain, leukocytosis and diarrhea. Invasion of the intestinal mucosa by Salmonellae causes activation of adenylate cyclase, increasing cyclic AMP levels and inducing secretion, possibly contributing to the diarrhea. Unlike Shigella and E. coli, Salmonellae do not escape the phagosomes, so the extent of intercellular spread and ulceration of t
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Some common words found in the essay are:
Barrali Pets, Pathogenic Salmonellae, Unlike Shigella, World Third-generation, Giannella Circulating, Non-typhoid Salmonellae, Non-typhoid Samonellae, XLT-4 SS, MCP-1 GM-CSF, World Taxonomically, enteric fever, inflammatory response, epithelial cells, acute inflammatory response, cause enteric fever, acute inflammatory, enteritis salmonella, causes enteritis, cause enteric, 30 nov 2005, strains salmonellae, causes enteritis salmonella, raw milk, 2005 30 nov, cause ulceration,
Approximate Word count = 1642
Approximate Pages = 7 (250 words per page)
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