Lymphocyte Response

1. Lymphocytes develop from stem cells in the bone marrow, and during fetal development, immature, undifferentiated lymphocytes are released from the bone marrow into the blood (Applegate, 2000, 295-296). Some of these cells go to the thymus gland, where they acquire the ability to distinguish between self and non-self and differentiate into T-lymphocytes. Differentiated T-cells leave the thymus and are carried by the blood to lymphoid tissues. Roughly 70 percent of circulating lymphocytes are T cells. T cells are responsible for cell-mediated immunity during which the T cells directly attack the invading antigen. Cell-mediated immunity is effective against virus-infected cells, cancer cells, foreign tissue transplants, fungi and protozoan parasites. The antigen is phagocytized by a macrophage on entering the body and presented

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