Role of Eosinophils in Asthma

The transgenic mice were created by lineage-specific expression of a cytocidal protein with a promoter fragment identified from studies of secondary granule protein genes expressed in mouse eosinophils. The researchers used EPO-derived sequences and diphtheria toxin A (DTA). The cytocidal character of DTA is mediated by the DTA A chain by the catalytic degradation of elongation factor-2 and the subsequent collapse of protein synthesis. The DTA B chain provides entry into the eukaryote cell.

Assessment of circulating leukocytes in the transgenic mice showed that the animals were devoid of eosinophils, but otherwise had a normal complement of hematopoietically derived cells. An examination of splenic cells revealed normal numbers of T and B cells an

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ine-induced airway hyperresponsiveness was dependent on eosinophils. Loss of eosinophils also led to improvement of other pulmonary function parameters associated with distal regions of the lung. This study has shown that eosinophils are responsible for at least some of the pathological effects in asthma. 61st Annual Meeting of the American Academy of Allergy, Asthma & Immunology, (2005). Retrieved Apr. 3, 2005 from: http://www.kyorin-pharm.co.jp/prodinfo/ConferenceInsight/ AAAAI/2005/505152063F0D4 Eosinophils are the dominant cell type in chronic inflammation and release cytotoxic proteins, reactive oxygen species, bioactive lipids and cytokines which damage the lining of airway passages in asthma patients. Eosinophils contribute to airway remodeling in patients with allergic asthma. Depletion of eosinophils in murine models decreases goblet cell metaplasia and mucus accumulation and abolishes airway hyperresponsiveness. Many asthma patients have sputum eosinophilia, and eosinophil levels correlate with symptom scores. This paper adds information relative to the paper I am discussing, and is from a reliable source. Behar, R., & Kibsey, M. (2001). Researcher probes link between asthma and bodyÆs immune syst
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