Tumor Suppressors

KhalKhakli-Ellis et al (2004) looked at the ability of hormones to regulate the expression of a serine protease inhibitor (serpin) which acts as a tumor repressor gene in breast cancer. The gene, known as maspin, plays a major role in the development of mammary gland development but is suppressed during the development of breast cancer. The researchers hypothesized that maspin expression was regulated by the drug Tamoxifen (TAM), a nonsteroidal-selective regulator of estrogen which is known to reduce the risk of both invasive and noninvasive breast cancer in women.

The study showed that TAM exerts its effects by inducing the tumor suppressor gene maspin

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Some common words found in the essay are:
Cancer Research, Manna Frazier, Tamoxifen TAM, MCF-7 HMEC133, P Frazier, Wong Ishida, breast cancer, Norwood Hendrix, cancer cells, breast cancer cells, et al 2004, protein kinase, al 2004, et al, breast cancer cell, cancer research, cancer cell, frazier 2004, gene maspin, human breast, human breast cancer, cell line mcf-7,
Approximate Word count = 642
Approximate Pages = 3 (250 words per page)

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