Tumor Suppressors

Khalkhali-Ellis, Z., Christian, A. L., Kirschmann, D. A., Edwards, E. M., Rezaic-Thompson, M., Vasef, M. A., Gruman, L. M., Seftor, R. E. B., Norwood, L. E., & Hendrix, M. J. C. (2004). Regulating the tumor suppressor gene maspin in breast cancer cells. Clinical Cancer Research, 10, 449-454.

KhalKhakli-Ellis et al (2004) looked at the ability of hormones to regulate the expression of a serine protease inhibitor (serpin) which acts as a tumor repressor gene in breast cancer. The gene, known as maspin, plays a major role in the development of mammary gland development but is suppressed during the development of breast cancer. The researchers hypothesized that maspin expression was regulated by the drug Tamoxifen (TAM), a nonsteroidal-selective regulator of estrogen which is known to reduce the risk of both invasive and noninvasive breast cancer in women.

The study showed that TAM exerts its effects by inducing the tumor suppressor gene maspin

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