Create a new account

It's simple, and free.

Passive Diffusion

(NOTE: You will have to change the results for passive diffusion: it just does not occur with lidocaine, according to all previously published results. I suggest you keep all absorbance readings below 0.006, and we will say any transport was due to artifact or experimental error.) Use results for passive diffusion and iontophoresis as obtained shown on same plot. For example:

Figure 1 shows the absorbance over the time course for the transportation of lidocaine from the donor compartment to the receptor compartment under conditions of passive diffusion: Figure 2 shows the absorbance over the time course for the transport of lidocaine from the donor compartment to the receptor compartment when an electrical current of 0.02mA was applied. There was very little passive diffusion of the lidocaine across the cellophane membrane. When a current was applied, the lidocaine concentration accumulated in the receptor compartment in a time-dependent manner. The cumulative transportation of lidocaine to the receptor compartment under conditions of passive diffusion can be seen in Table 1. The cumulative transportation of lidocaine to the receptor compartment under iontophoretic conditions can be seen in Table 2.

A roughly linear relationship was achieved for iontophoretic transfer of lidocaine from the donor compartment to the receptor compartment. It was not possible to obtain readings at different currents because it was difficult to keep the gel in place because it was an irregular shape which gave it a high resistance and it was not possible to work with it at higher currents. The maximum current which could be passed through the cellophane membrane was 0.02 mA.

The typical Higuchi curve, which describes the release of product over time from an insoluble matrix over time, shows a lag phase while the product enters the matrix, followed by a steep curve as the drug is delivered from the matrix to the skin, and then the cur...

Page 1 of 12 Next >

More on Passive Diffusion...

Loading...
APA     MLA     Chicago
Passive Diffusion. (1969, December 31). In LotsofEssays.com. Retrieved 09:03, March 28, 2024, from https://www.lotsofessays.com/viewpaper/1712956.html