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Creatine Phosphokinase and Isoeletric Focusing

Creatine Phosphokinase (CPK) refers to an enzyme that is typically found in the brain, heart, and skeletal muscle. CPK is also referred to as creatine kinase. The CPK test was developed to determine how much CPK is currently in the blood and identify excess levels of CPK in the blood to diagnose disease states (Anderson, 2007; Barohn, 2007; General Practice Notebook, 2010; Health Grades, 2010; Medicine Online, 2002; Medline Plus, 2010).

This test is performed by drawing blood for the vein. A needle is inserted into the vein and the blood is collected. There is no special preparation for this test however certain drugs may increase the measurements of CPK, such as ampicillin, anesthetics, amphotericin B, aspirin, blood thinners, furosemide, alcohol, cocaine, clofibrate, and dexamethasone. When CPK levels are high this typically indicates that there has been a stress or injury to the brain, heart, or muscle tissue. Then this takes place, CPK is leaked into the bloodstream. The form of CPK found in excess indicates the tissue that is injured or damaged (Anderson, 2007; Barohn, 2007; General Practice Notebook, 2010; Health Grades, 2010; Medicine Online, 2002; Medline Plus, 2010).

CPK also referred to as CK enzymes have two sub-units referred to as B for the brain type or M for the muscle type. Three different isoenzymes include: CK-BB (CPK1), CK-MB (CPK2, and CK-MM (CPK3). These three sub-units are cytosolic CK isoforms and there are also two mitochondrial creatine kinase isoenzymes called the ubiquitious and sarcomeric forms. The genes for these units are found on different chromosomes as follows: B is found on 14q32 and M is found on 19q13. The CK-BB is found in all tissues and levels are low and rarely significant in the bloodstream or relevant to clinical issues. CK-M is found in the skeletal muscle at levels of 98% with low levels of 1%. The heart muscle or myocardium expresses CK-MM at 70% an...

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Creatine Phosphokinase and Isoeletric Focusing. (1969, December 31). In LotsofEssays.com. Retrieved 18:44, March 28, 2024, from https://www.lotsofessays.com/viewpaper/2001250.html