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Genetic Basis & Biochemical Components of Lesch-Nyhan Syndrome

tion of the same gene, leading to reduced, but not eliminated, HPRT activity. A partial deficiency may also result in nephrolithiasis, gouty arthritis, and some neurological manifestations.

HPRT is located on the x-chromosome and is a recessive trait, so only males are affected. Since male Lesch-Nyhan patients are not capable of fathering children, women can be carriers of the syndrom

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Genetic Basis & Biochemical Components of Lesch-Nyhan Syndrome. (1969, December 31). In LotsofEssays.com. Retrieved 07:07, March 28, 2024, from https://www.lotsofessays.com/viewpaper/1698924.html