rs on major depression. However, these studies have suffered from substantial limitations, including reliance on cross-sectional assessments, neglect of important risk factor domains, and possibly, suboptimal analytic strategies. For example, currently there are only two studies that have included measures of family background and none that have directly assessed the impact of genetic factors. In addition, in developing meaningful etiologic models of psychiatric disorders, a central goal should be to clarify the causal processes that interconnect risk factors. That is lists of statistically significant predictor variables should be co
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