Red Blood Cell Disorders
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Describe the composition of blood, function and lifespan of each cell type, and the process of erythropoiesis. Blood consists of plasma containing water, organic and inorganic solutes, and both red (erythrocytes) and white cells (Cytopenia; Applegate, 2000, 229-233). Erythrocytes contain hemoglobin which transports oxygen from the lungs to the tissues and carbon dioxide from the tissues to the lungs. Their lifespan is approximately 120 days. Erythrocyte production is controlled by a negative feedback mechanism by the hormone erythropoietin, which is produced by the liver and activated by renal erythropoietic factor from the kidneys, which stimulates the red bone marrow to produce erythrocytes. The white cells (lifespan 1-3 days) consist of neutrophils (phagocytes), eosinophils (involved in allergic reactions and destruction of parasitic worms), basophils (contain histamine and the anticoagulant heparin), lymphocytes (involved in immune response), monocytes (phagocytes, become macrophages on leaving bloodstream), and thrombocytes (platelets, involved in blood clotting, lifespan 10 days). Compare the characteristics of the following forms of anemia: -iron deficiency anemia is caused by most commonly by blood loss (Berkow, Beers and Fletcher, 1997, 743) - may be due to dietary deficiency in infants and small children. -Pernicious anemia is caused by inadequate absorption of vitamin B12 because the stomach does not produc
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ponade - serious complication of pericarditis from fluid accumulation or bleeding into pericardium from tumor, injury or surgery; can be caused by viral or bacterial infection or kidney failure; blood pressure may fall rapidly causing cardiac emergency; needle or surgical drainage necessary; pressure from fluid stops heart expanding fully, reducing cardiac output (104-106.
Define the term cardiomyopathy (progressive disorder that alters the structure or impairs the function of the muscular wall of the ventricles) and compare the following myopathies:
-dilated - dilated congestive cardiomyopathy is a group of heart disorders in which the ventricles enlarge, and are not able to pump enough blood for the body's needs, resulting in heart failure
-hypertrophic - a group of heart disorders in which the walls of the ventricles thicken
-constrictive - a group of disorders in which the walls of the ventricles become stiff, but not necessarily thickened, and resist normal filling with blood between heartbeats (90-93).
Distinguish among the pathology, causes, and treatment of:
-infective endocarditis - bacterial (rarely fungal) infection entering bloodstream (or from surgery) lodge on heart valves and infect the endocardium
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Approximate Word count = 9292
Approximate Pages = 37 (250 words per page)
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