on of CF occurred in the summer of 1951. That year a heatwave struck New York. Concomitantly, the researcher, Di Sant' Agnese, noted an abundance of cystic fibrosis afflicted children being treated for heat prostration (1:791). Upon further investigation, he discovered that the children's sweat contained an excess of sodium and chloride. This observation eventually led to a diagnostic test. In 1959, Gibson and Cooke developed the pilocarpine sweat test for the diagnosis of CF. Basically it involves quantitative analysis of sodium and chloride concentrations in sweat collected through pilocarpine iontophoresis stimulation (10:4). The technique is still in widespread use today.
Yet another major milestone for CF occurred
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