or high concentrations will cauterize the tissue. Negatan is highly acidic and decalcifies the teeth. When very high concentrations or amounts od epinephrine are applied locally to lacerated tissue, epinephrine can be absorbed and cause an increase in the heart rate and blood pressure, which could be dangerous for patients with cardiovascular disease, hyperthyroidism, and to certain hypersensitive individuals. The application of epinephrine to large areas od lacerated or abraded gingival tissues should be avoided (94).
Monsel's solution (20 percent aqueous ferric subsulfate) is prepared by reacting ferric sulfate with sulfuric acid and nitric acid (2:203). It has been used as a powerful styptic for over 100 years. Its mechanism of action is that of a local protein precipitate and platelet activator (56:498). The membrane of coagulated proteins mechanically seals small blood vessels (14:227). Hemostasis by Monsel's solution is believed to result from the capacity of ferric ions to denature and agglutinate proteins, including fibrinogen. It is thought t
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