ions in physical activity, diet, and medical history, poor correlation between symptoms of OA and radiographic lesions, and inabilities to detect early disease. Animal studies attempt to further the understanding of OA. Naturally occurring OA in young adult female cynomolgus monkeys (closely resembling the human disease) shows articular cartilage changes suggesting a thickening of the subchondral plate as a feature of early lesions. An increase of thickness in the subchondral bone plate in the medial tibial plateau in the early stages of OA has been demonstrated. This is followed by an increase in subchondral bone thickness in the lateral tibial plateau and femoral condyles (later stages of the disease) (3).
Pathogenesis of OA includes many contributions such as genetic, environmental, metabolic, and biomechanical factors. Genetic factors in OA, such as gene mutations, interact with environmental factors such as occupation, lifestyle, and joint trauma, to influence the developm
...