y ordered process involving individual replicons being synthesized at precise times. The article then goes into a very technical discussion including such topics as the identification of nascent strand sites, the determination of replication timing, and the analysis of fork direction. Clearly, the mammalian origins of DNA replication are very complex. In general though, replication starts with the binding of an initiator protein to a replicator in the presence of chromatin. This multi-enzyme complex then initiates a new strand of DNA.
4.Huberman, J. A. A licence to replicate. Nature. 375:360-361; 1995, June 1.
This short article actually summarizes the results of 3 different papers on replication licensing factors. For example, it states that researchers have determined that the factor is composed of proteins belonging to the minichromosome maintenance (MCM) family. These genetically interacting proteins have been found to selectively destabilize replication-origin-dependent circular chromosomes in yea
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