Advisory Council for Human Genome Research (NACHGR), and the extramural research community. The DER oversees such major areas of human genome research as: the development of technologies for gene sequencing and mapping; the analysis of gene function and the proteins for which they encode; computer technology developed to manage and disseminate the data generated by the HGP; determining the crucial differences in the genetic makeup of individuals from each other; and the examination of ethical, legal, and moral implications arising from genetic research. Implicit in such oversight is control of the quality of HGP research.
Process-oriented quality measures are essential for maintaining the efficiency of sequencing and for generating reliable quality data (Rowan, Mahairas and Hood, 1997). Personnel need to be properly trained and sequencing precision is essential. Programs can assign a quality measure to each base in a consensus sequence. Contiguity can be controlled by sequence assembly programs, and by the successful overlapping of sequences from adjacent clones. Clone integrity and validity can be checked by fingerprint comparisons of clones against overlapping clones, or directly against genomic DNA.
In 1997 at the Second International Strategy Meeting on Human Genom
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