Sickle Cell Anemia Discussion

Sickle cell disease is a common monogenetic disorder found worldwide that affects 30 million people (Inati, Koussa, Taher, & Perrine, 2008). Sickle cell anemia is an interesting and important area of chemistry because, as noted by Inati et al., this disease is a major public health concern linked to morbidity and mortality. Anemia is the most common hematologic problem found in children and 30% of children have anemia. Thus, it is important to diagnose the type of anemia to determine if the child suffers from sickle cell anemia (Inati, 2008). Sickle cell disease varies phenotypically and people vary in symptoms ranging from severe with death at a very young age to hardly noticeable until adulthood. These multiple manifestations are related to different complications that have the potential to affect each aspect of the patient's life.

Clinical manifestations of a common and severe type include self-limited pain with acute chest syndrome, stroke, acute splenic sequestration, joint necrosis, hepatic sequestration, and organ failure to include renal disease and functional asplenia. Manifestations of another ty

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