Signs include increased height, long disproportionate limbs and digits, deformity in the anterior chest, joint laxity, and deformity in the vertebral column with scoliosis and/or thoracic lordosis. The Marfan patient tends to be tall, slender, and loose-jointed with disproportionately long arms, legs, fingers, and toes. The curvature of the spine can be severe without treatment. The breastbone (sternum) may protrude or indent. The lower jaw may recede accentuating an overbite. Deeper set and older appearing eyes are found in infants. Skeletal features of a narrow face, prominent ears with pointed appearance, and high arched palate and teeth crowding are found (OMIM, 2002; Pyeritz & Casner, 1999).
Symptoms also include ocular features of increased axial globe length, flat cornea, moderate to severe myopia, iris tremor, deep anterior chamber angle, and lenses subluxation or ectopia lentis. In around 70% of Marfan cases, the lens of the eye is off-center o
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