Indian leaders came when Andrew Jackson ignored the Cherokees' legal rights - rights supported by the Supreme Court - and expelled them from Georgia along the infamous "Trail of Tears."
The inevitable push of a stronger power on a weaker people was repeated on the African slaves brought into the colonies - with somewhat happier results only as a result of a changing moral suasion the Indians never enjoyed.
Almost from the beginning of European colonization Africans were brought over as slave labor, a necessity brought on by the decimation of Native American locals from European disease. The Spanish were the first to need such imported labor - Africans from the equatorial regions being physically suited to Caribbean labor and more resistant to disease due to their longer contact with Europeans - but the English South Atlantic coastal settlers quickly understood slave value as well: indentured white workers were dying off like flies, replacements were difficult to "recruit" - who would willing chose to submit themselves to such conditions?
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