uced the oxidative stress and blocked ?-glutamyl transpeptidase activity.
These results showed that at physiological levels, androgens can increase oxidative stress in LNCaP cells, and that this is probably partially due to increased mitochondrial activity (1). Androgens were also shown to alter levels of intracellular glutathione levels, which are important factors in the control of prooxidant-antioxidant levels in cells (1). Androgen levels decrease with age, but oxidative stress increases, and it is speculated that this increase in oxidative stress may be linked to the cause of prostate cancer. Oxidative stress is known to disturb the levels of antioxidants and antioxidant enzymes, and this may allow reactive oxygen species to damage DNA, or the disturbance in the redox balanc
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