-1 (CLA-1 and this promotes cell growth. HDL is also thought to have apoptotic effects on some cell types. The HDL effect is known to be more prominent in ER+ than in ER- cell.
CLA-1 is primarily found in the liver and steroidogenic tissues such as mammary gland cells (Cao et al, 2004). Other studies have shown that breast cancer cells acquire cholesterol from HDL in a CLA-!-mediated process. Cao et al assessed the functions of CLA-1 and HDL on human breast cancer cells using a mutant CLA-1 (mCLA) from which the COOH-terminal segment had been removed to see if it played a role in breast cancer growth.
There is considerable variation in the chemotherapeutic response of breast cancers which may be attributed to variations or defects in programmed cell death pathways, according to Manna and Frazier (2004), since a variety of growth factors oppose cell death. Evidence has been building for a role of thrombospondins (TSPs) 1 and 2 as antitumor factors for breast cancer. The primary effect of TSPs is binding to CD36, a TSP receptor expr
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