mostly CK-MM with CK-MB rates of less than 65. CK-MB is found to exceed 5% only in the heart tissue except in patients with muscle disease or athletes with skeletal muscle content of up to 5-15% of CK-MB may be found. Normal ranges of CK levels in women are 24-170 Unites/litre and 24-195 in men (General Practice Notebook, 2010).
CK rises following myocardial infarction with a total CK peak value at 18 to 30 hours and a duration of two to five days at a level that is 5 to 10 times more than normal. CK-MB has a peak value 12 to 24 hours later with a duration of 1.5 to 3 days at levels that vary. The CK increase is proportional to the infarction extent and total CK is 98% sensitive. However, CK is only from 65% to 85% sensitive or specific for acute myocardial infarction and CK-MB is more specific. Since total CK and CK-MB rise earlier and are smaller for infarction it is hard to distinguish between infarction and cardiac surgery post-operatively (General Practice Notebook, 2010).
CK in skeletal muscle disease such as muscu
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